At Molecular Diagnostics and Therapy, an NABL & NABH Accredited Diagnostic Centre, get your Anti-A Titre Profile, a Serum Test. Anti-A Titre Profile is a blood test that tests for the level of antibody against the blood group A antigen in the blood serum. It assists physicians in determining ABO blood group incompatibility and the intensity of immune response, especially in the pre-transplant assessment, organ transplantation, and other clinical situations where levels of antibodies specific for blood groups should be monitored.

What Is Anti-A Titre Profile, Serum Test?

Anti-A Titre Profile, Serum Test is a blood test that measures antibody levels against the A blood group antigen. This test is typically done by diluting the serum from the patient serially and testing with A antigen cells. The antibody titre is the lowest dilution of the product that shows an antibody reaction. The greater the amount of dilution, the more antibody reaction is present and the higher the titre will be. The type of profile may vary depending upon the testing method and can contain IgM and IgG anti-A antibodies. The results are helpful for the assessment, treatment planning, and follow-up of blood group-specific antibodies during transplantation.

Common Reasons for Anti-A Titre Profile, Serum Test

• Anti-A antibody level pretransplant: To determine the A antibody level before an organ transplant between people of blood types.
• Kidney Transplant Assessment: ABO-incompatible kidney transplantation (KTx) patients' blood group-specific antibody.
• Antibody Level Monitoring: To monitor anti-A antibody levels during the preparation for transplant and follow-up.
• Blood Group Incompatibility: Tests to check for the presence of blood group antibodies and their strength.
• Treatment Planning: To help the doctor plan treatment effectively if clinically important antibody(s) are found.
• Immunological Evaluation: To evaluate the immune response to the A blood group antigens in specific clinical situations.
• Desensitisation Monitoring: To see if antibody levels are dropping during treatment to reduce levels of blood group-specific antibodies prior to transplant.

Conditions and Clinical Situations Evaluated

ABO Blood Group Incompatibility

It is a test of antibodies to A blood group antigens in people who lack the A antigen on their red blood cells. These antibodies may play a role in deciding whether or not an organ donor is compatible with a recipient.

ABO-Incompatible Kidney Transplantation

Immunoglobulins (antibodies) against the blood group ABO antigens of the donor may be present in the recipient in the case of ABO-incompatible renal transplantation. Anti-A antibody titres are used to ascertain the level of antibody response, to assist in planning appropriate pre-transplant management.

IgM and IgG Antibody Response

In the laboratory testing procedure, there may be separate tests for IgM and IgG anti-A antibodies. The antibody classes exhibit different immunological properties and may give further clues to the patient's antibody response.

Pre-Transplant Immunological Assessment

Pre-transplant anti-A titre may be ordered for certain individual patients. It helps doctors understand the antibody profile (which will be present in the recipient's blood group) and helps them to plan the transplantation.

Post-Transplant Antibody Monitoring

Repeat antibody titre after transplantation may be considered in some cases to determine the antibody titre change and assist with the clinical follow-up.

Monitoring During Desensitisation Treatment

In cases where treatment to reduce blood group-specific antibodies has been administered before an ABO-incompatible transplant, another titre may be necessary. The results are utilized to determine antibody changes and the patient's response to treatment by the transplant team.

Why Choose Molecular Diagnostics and Therapy?

Molecular Diagnostics and Therapy is an NABL & NABH Accredited Diagnostic Centre providing the latest in all the fields of radiology, nuclear medicine and pathology services in a single place. The use of modern diagnostic infrastructure, experienced laboratory professionals, standardized testing procedures, and patient-focused care is key to our laboratory services. High standards in quality and consistent testing procedures are emphasised to ensure that diagnostic assessment is correct and that the report is sent as quickly as possible.

Book Your Anti-A Titre Profile, Serum Test

For information and appointments on conducting an Anti-A Titre Profile and/or a Serum Test, please contact Molecular Diagnostics and Therapy. Bring your doctor's prescription, previous antibody tests, blood group reports, and previous medical records concerning transplants. Let the lab staff know if you have recently received any blood transfusion or transplant, or are still receiving treatment.