Advanced Pathology & diagnostic centre laboratory services provider Molecular Diagnostics and Therapy with an NABL and NABH Certification has detailed information on Anti-B Antibody Titre Test available on their website. Anti-B Antibody Titre Test determines the amount of antibody against the B blood group antigen in the blood of a person. It helps the doctor assess the nature and level of the blood group-specific antibodies, as well as the power of the immune reaction in pre-transplant blood tests, organ transplantation, and other situations where blood group-specific antibody monitoring is required.

What Is Anti-B Antibody Titre Test?

Anti-B Antibody Titre Test (ABA) is any test performed in the laboratory that measures the antibody activity to the blood group ‘B’ antigen. This is usually accomplished by an immunohaematological process of serial dilutions of the patient's serum. The diluted serum is then tested to see if there is an antibody reaction with the B antigen attached to the red cell. The titre is the highest dilution at which the antibody still reacts. A higher titre means more antibody, as this means the more dilution that can be done where the antibody still reacts with the sample. Different laboratories may measure IgM, IgG, or total antibody anti-B (against the B antigen) in the test depending on the method used to perform the test and the clinical need.

Common Reasons for Anti-B Antibody Titre Test

• Kidney Transplant Evaluation: To evaluate ABO-incompatible kidney transplantation for those who are thinking of a kidney transplant.
• The monitoring of anti-B antibody titres (ALM): Monitoring of changes in anti-B antibody titre during transplant preparation & follow-up.
• Blood group incompatibility: To test for blood group antibodies and their level.
• Treatment Planning: Antibodies provide information to doctors to create a treatment plan, if clinically significant.
• Immunological Evaluation: This is a test to evaluate the immune response to B blood group antigens in certain clinical situations.
• Repeat antibody titre testing: Post-transplant monitoring: If antibody titre monitoring is warranted by the treating specialist.

Conditions and Clinical Situations Evaluated

ABO Blood Group Incompatibility

The test can be helpful to assess antibodies to the B blood group antigen in persons who lack a B antigen on their red blood cells. These antibodies may play a role in making sure that an organ recipient and donor are compatible.

ABO-Incompatible Kidney Transplantation

During ABO-incompatible kidney transplantation, the recipient might have antibodies against the blood group antigens of the donor. Anti-B antibody titres are useful in determining the antibody response and for planning the appropriate management that is required prior to the transplant.

Blood Group-Specific Antibody Response

Contains information on antibody response to B antigens. Depending on the method of testing, it can be used to evaluate the antibody response (IgM and IgG).

Pre-Transplant Immunological Assessment

Pre-transplant measures of anti-B antibody titre might be performed in some patients. It helps doctors check the antibody profile of the blood group of the recipient before the transplantation.

Post-Transplant Antibody Monitoring

In some cases, anti-B antibody titres are selected after transplantation for monitoring antibody levels to support the clinical course.

Monitoring During Desensitisation Treatment

In patients who have received pretransplant therapy to reduce the blood group-specific antibodies, repeat titres may be required before an ABO-incompatible transplant. The results contribute to the team's ability to keep track of antibody levels and evaluate the effects of the treatment.

Why Choose Molecular Diagnostics and Therapy?

Molecular Diagnostics and Therapy is a NABL and NABH Accredited Diagnostic Centre to provide end-to-end services across Radiology, Nuclear Medicine and Pathology. Our laboratory is equipped with the latest diagnostic technologies, highly skilled laboratory personnel, a well-defined testing protocol, and patient-centered services. Quality Control is used mainly as a reliable testing system to guarantee quality and prompt reporting for diagnosis.

Book Your Anti-B Antibody Titre Test

If your doctor has recommended you have an Anti-B Antibody Titre Test, then contact Molecular Diagnostics and Therapy and arrange when this test will be taken and what information can be relied upon. Bring your doctor’s prescription, any previous antibody titres, blood group reports, and any relevant medical records which pertain to your transplant, if available. Notify us of any blood transfusion, transplant, or other therapy that has been carried out in recent time.