Molecular Diagnostics and Therapy is an advanced diagnostic centre that is NABL-accredited and NBAH-accredited. Antibody to B antigen (IgG) is a blood test that measures the level of IgG antibodies against the blood group B antigen. This test is used to identify the amount of IgG antibodies in patients during the pre-transplant evaluation for ABO-incompatible organ transplants.
The Anti-B Titre IgG test is a specific immunohaematology test to detect IgG antibodies against the B antigen found on red blood cells. The patient's serum/plasma is generally mixed with blood cells containing the B antigen in the test. Levels of antibody are measured. The titre is the highest dilution of the patient’s sample at which an antibody reaction can still be seen. The outcome will be discussed taking into consideration reasons for transplant, history of the patient, and techniques used in the lab to achieve this outcome.
An test which will assist to identify if the recipient antibody is also against the donor's B blood group antigen. An ABO-incompatible transplant is when there is a mismatch in the blood type of the donor and recipient.
An antibody reaction may occur if the recipient of the transplant has antibodies against the blood group antigens of the donor. The Anti-B IgG titre will provide some clues to the doctor as to how to assess this risk.
This test identifies the amount of antibody ( IgG ) against the B antigen. This should enable doctors to calculate the levels of antibodies.
In certain transplant patients, it may be suggested to do this procedure again. This is useful for surveillance of any changes in the anti-B IgG. This is taken into account with organ function, the patient's findings, and additional investigations.
In the event of blood group type differences between the organ donor and recipient, tests for anti-B IgG titre can be part of the organ/recipient compatibility assessment.
Molecular Diagnostics and Therapy provides cutting-edge diagnostic care throughout the Radiology/ Nuclear Medicine/ Pathology departments. Correct sample collection, special tests, and expert patient reporting by our pathologists. Reliable diagnostic support is our aim.
If you've been recommended to undergo this test, please get in touch with us for extra information. Take along your doctor's prescriptions and any old blood group antibody or medical notes from your transplant. For transplant having this test please check with your team if there are any peculiar requirements to collect.
Test information: No fasting is usually required. Follow your doctor's or laboratory's instructions.
Reporting: Within 24 hours*