Bipolar Disorder: Causes, Symptoms, Types & Tests

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28 Jul, 2025

Dr. Nikunj Jain

Dr. Nikunj Jain

Co-Founder and HOD - Nuclear Medicine ,

MBBS, DRM, DNB, FEBNM, FANMB, Dip. CBNC

Bipolar disorder is a mental health condition characterized by extreme mood swings that include emotional highs (mania or hypomania) and lows (depression). Unlike typical mood fluctuations everyone experiences, these shifts are intense, can last for days or weeks, and significantly impact daily life, relationships, and work. Though bipolar disorder is lifelong, effective treatment plans—including medication, therapy, and lifestyle adjustments—can help individuals manage mood episodes and lead stable, fulfilling lives.

Bipolar Disorder

Bipolar disorder is defined as a chronic mood disorder involving alternating episodes of mania (or hypomania) and depression. It affects about 1–2% of the global population and often begins in late adolescence or early adulthood. The disorder varies widely among individuals: some may experience frequent mood episodes each year, while others might go years without major symptoms. During manic episodes, people often feel overly energetic, euphoric, or unusually irritable. In contrast, depressive episodes bring feelings of sadness, hopelessness, and loss of interest in daily activities. These shifts are more severe than ordinary ups and downs and can disrupt relationships, jobs, and personal goals.

Causes of Bipolar Disorder

The exact cause of bipolar disorder remains unclear, but it likely results from a combination of biological, genetic, and environmental factors:

  • Genetic factors: Family history plays a significant role. Individuals with a parent or sibling with bipolar disorder have a higher risk.
  • Brain structure and function: Imaging studies show differences in the brains of people with bipolar disorder, particularly in areas controlling mood regulation.
  • Neurochemical imbalances: Fluctuations in neurotransmitters like serotonin, dopamine, and norepinephrine may contribute to mood episodes.
  • Environmental triggers: Stressful life events—such as trauma, abuse, major life changes, or substance use—can trigger or worsen mood episodes in people predisposed to the disorder.

Importantly, while genetics increase risk, not everyone with a family history develops bipolar disorder, underscoring the complex interplay of factors.

Symptoms of Bipolar Disorder

Bipolar disorder symptoms depend on the phase—mania, hypomania, or depression. Episodes may last from days to weeks, and severity varies.

Manic episode symptoms:

  • Elevated, expansive, or irritable mood lasting at least a week.
  • Inflated self-esteem or grandiosity.
  • Decreased need for sleep (e.g., feeling rested after only a few hours).
  • Increased talkativeness or pressure to keep talking.
  • Racing thoughts or rapid speech.
  • Distractibility.
  • Risky behaviors (e.g., overspending, impulsive decisions, substance use).

Hypomanic episode symptoms:

  • Similar to mania but milder and lasting at least four days.
  • Often noticeable by others but less likely to cause severe disruption.

Depressive episode symptoms:

  • Persistent sadness or emptiness.
  • Loss of interest in activities once enjoyed.
  • Significant changes in appetite or weight.
  • Fatigue or low energy.
  • Difficulty concentrating or making decisions.
  • Feelings of guilt or worthlessness.
  • Thoughts of death or suicide.

Between episodes, many people return to their usual mood and functioning, though some experience lingering mild symptoms.

Types of Bipolar Disorder

Bipolar disorder is generally classified into several types based on mood patterns and episode severity:

1. Bipolar I disorder:

  • Defined by at least one manic episode, lasting at least seven days or requiring hospitalization.
  • Depressive episodes usually occur as well, often lasting at least two weeks.

2. Bipolar II disorder:

  • Characterized by at least one hypomanic episode and at least one major depressive episode.
  • No history of full manic episodes.
  • Often misdiagnosed as depression due to milder hypomania.

3. Cyclothymic disorder (cyclothymia):

  • Periods of hypomanic and depressive symptoms over two years (one year in children/adolescents) that don’t meet full criteria for mania or major depression.
  • Symptoms may still cause distress and functional challenges.

4. Other specified and unspecified bipolar and related disorders:

  • For individuals whose symptoms don’t fit neatly into the above categories but still show clinically significant mood disturbances.

The type determines the treatment approach, highlighting the need for accurate diagnosis.

Tests Used to Detect Bipolar Disorder

There is no single lab test to confirm bipolar disorder. Diagnosis relies on thorough clinical evaluation and history-taking:

  • Psychiatric assessment: A mental health professional asks about mood, behavior, lifestyle, family history, and previous episodes.
  • Mood charting: Patients may track daily mood, sleep, and activities to identify patterns.
  • Structured interviews and questionnaires: Tools like the Mood Disorder Questionnaire (MDQ) help screen for bipolar symptoms.
  • Physical examination: To rule out medical conditions (e.g., thyroid disorders) that can mimic mood symptoms.
  • Lab tests: Blood tests may check thyroid function, vitamin levels, or screen for substance use that can influence mood.

Early and accurate diagnosis is critical to avoid mislabeling bipolar disorder as depression alone, which can lead to inappropriate treatment.

Conclusion

Bipolar disorder is a serious mental health condition that goes beyond everyday mood swings. It’s marked by alternating episodes of mania or hypomania and depression, each deeply affecting energy, behavior, and relationships. While its exact cause remains complex, involving genes, brain chemistry, and life experiences, awareness and understanding of the disorder have grown significantly in recent decades. Importantly, bipolar disorder is manageable. Early diagnosis, mood-stabilizing medications, psychotherapy, lifestyle changes like consistent sleep, stress management, and support networks can help people lead balanced, productive lives. Education and reducing stigma around mental health also empower individuals and families to seek timely help.

Frequently Asked Questions (FAQ’s)

1. What is bipolar disorder?
Bipolar disorder is a mental health condition marked by extreme mood swings, including manic or hypomanic highs and depressive lows.

2. At what age does bipolar disorder typically begin?
It often starts in late adolescence or early adulthood, typically between ages 15 and 25.

3. Can bipolar disorder be cured?
There is no cure, but symptoms can be managed effectively with treatment.

4. What triggers bipolar episodes?
Stress, sleep disruption, substance use, and major life changes can trigger episodes.

5. Is bipolar disorder hereditary?
Yes, family history increases risk, though not everyone with a family link develops it.

6. What is the difference between mania and hypomania?
Mania is more severe, can lead to hospitalization or psychosis; hypomania is milder and less disruptive.

7. Can someone with bipolar disorder live a normal life?
Yes, many people live stable, fulfilling lives with proper treatment and support.

8. Why is bipolar disorder sometimes misdiagnosed?
Because depressive episodes may look like major depression, and hypomania can be overlooked.

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