Depression: Causes, Symptoms, Types & Tests

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28 Jul, 2025

Dr. Nikunj Jain

Dr. Nikunj Jain

Co-Founder and HOD - Nuclear Medicine ,

MBBS, DRM, DNB, FEBNM, FANMB, Dip. CBNC

Depression is one of the most common mental health disorders affecting people of all ages worldwide. Often misunderstood as simple sadness or weakness, it is, in fact, a complex medical condition that deeply impacts mood, thoughts, behavior, and even physical health. It can interfere with daily activities, relationships, work, and overall quality of life. The good news is that depression is treatable, and early recognition combined with proper care can lead to significant improvement or even full recovery.

Depression

Depression, clinically known as major depressive disorder (MDD), is a mood disorder marked by persistent feelings of sadness, hopelessness, and loss of interest or pleasure in daily activities. It affects how a person feels, thinks, and manages everyday responsibilities. Unlike normal emotional responses to life’s challenges, depression lingers for weeks or months and can become severe enough to disrupt one’s ability to function. Depression is not a sign of weakness, nor something people can simply “snap out of.” It is a medical condition influenced by biological, psychological, and social factors, requiring understanding, support, and often professional treatment.

Causes of Depression

Depression doesn’t have a single cause; instead, it typically results from a combination of several risk factors:

  • Biological factors: Imbalances in brain chemicals (neurotransmitters) like serotonin, norepinephrine, and dopamine.
  • Genetics: Family history increases the risk, suggesting a hereditary link.
  • Psychological factors: Trauma, low self-esteem, and chronic stress can all contribute.
  • Medical conditions: Chronic illnesses such as diabetes, heart disease, and hormonal disorders like thyroid disease.
  • Medications: Some drugs have side effects that can lead to depressive symptoms.
  • Substance abuse: Alcohol and drug misuse can trigger or worsen depression.
  • Life events: Loss of a loved one, relationship problems, financial difficulties, or major life transitions.

Symptoms of Depression

Symptoms can vary from person to person, but common signs include:

  • Persistent sadness or low mood: Nearly every day, lasting weeks or longer.
  • Loss of interest or pleasure: Even in activities once enjoyed.
  • Changes in appetite or weight: Eating too little or too much.
  • Sleep disturbances: Trouble falling asleep, staying asleep, or sleeping excessively.
  • Fatigue or low energy: Feeling tired despite adequate rest.
  • Feelings of worthlessness or guilt: Often disproportionate to actual circumstances.
  • Difficulty thinking or concentrating: Trouble making decisions or remembering details.
  • Restlessness or slowed movements: Noticeable changes in physical activity.
  • Thoughts of death or suicide: In severe cases.

Types of Depression

Depression comes in several forms, including:

1. Major Depressive Disorder (MDD):
The most common type, with symptoms lasting at least two weeks, significantly impacting daily life.

2. Persistent Depressive Disorder (Dysthymia):
Long-term (often two years or more) depression with milder but chronic symptoms.

3. Bipolar Disorder (formerly manic depression):
Alternating episodes of depression and mania (periods of unusually high energy or irritability).

4. Seasonal Affective Disorder (SAD):
Depression linked to seasonal changes, typically worsening in winter months.

5. Postpartum Depression:
Occurs after childbirth, affecting mothers emotionally and physically.

6. Atypical Depression:
Depression marked by mood improvement in response to positive events but other symptoms like increased appetite and sleep.

Tests Used to Detect Depression

There’s no single lab test to diagnose depression, but doctors use several tools:

  • Clinical evaluation: A detailed conversation about symptoms, lifestyle, and history.
  • Psychological questionnaires: Such as the PHQ-9 or Beck Depression Inventory to assess severity.
  • Physical examination: To rule out medical conditions that may mimic depression.
  • Blood tests: Checking thyroid function or vitamin levels that can affect mood.
  • Mental health referral: Sometimes a psychiatrist or psychologist conducts specialized assessments.

Conclusion

Depression is more than temporary sadness—it’s a serious health condition that can affect anyone, regardless of age, background, or lifestyle. Understanding the causes, recognizing the symptoms, and seeking help early are crucial steps toward recovery. Treatment often involves a combination of therapy, medication, lifestyle changes, and support from family and friends. Importantly, depression is treatable. With the right care and resources, many people lead fulfilling, balanced lives despite having faced depression.

Frequently Asked Questions (FAQ’s)

1. What is depression?
Depression is a medical condition marked by persistent sadness, hopelessness, and loss of interest in daily activities.

2. What causes depression?
It can result from genetics, brain chemistry, life stress, medical illnesses, or substance abuse.

3. Is depression treatable?
Yes, with therapy, medication, lifestyle changes, and support, many people recover or manage symptoms effectively.

4. Can depression go away on its own?
Sometimes mild episodes improve naturally, but persistent or severe depression usually requires treatment.

5. How long does depression last?
It varies; some episodes last weeks, while others may become chronic without treatment.

6. Are there physical symptoms of depression?
Yes—fatigue, appetite changes, headaches, and sleep problems often accompany emotional symptoms.

7. Does depression affect children and teens?
Yes, it can affect people of all ages, including children and adolescents.

8. How is depression diagnosed?
Through clinical interviews, psychological assessments, and sometimes physical tests to rule out other causes.

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