HIV/AIDS: Causes, Symptoms, Types & Tests

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28 Jul, 2025

Dr. Nikunj Jain

Dr. Nikunj Jain

Co-Founder and HOD - Nuclear Medicine ,

MBBS, DRM, DNB, FEBNM, FANMB, Dip. CBNC

HIV/AIDS remains one of the world’s most recognized yet often misunderstood health conditions. Human Immunodeficiency Virus (HIV) weakens the immune system, making the body vulnerable to infections and certain cancers. Without timely treatment, HIV can progress to Acquired Immunodeficiency Syndrome (AIDS), the most severe stage of infection. Thanks to modern medicine, particularly antiretroviral therapy (ART), people living with HIV can now lead long, healthy lives. Early detection, regular monitoring, and proper treatment remain essential to controlling the virus and preventing its progression to AIDS.

HIV/AIDS

HIV is a virus that attacks the immune system, specifically targeting CD4 cells (also known as T cells), which help the body fight off infections. Over time, if left untreated, HIV can reduce the number of these cells so severely that the immune system becomes too weak to fight off infections and certain cancers. When this happens, HIV progresses to AIDS. AIDS is not a separate disease but rather a syndrome—a collection of symptoms and infections associated with the severe weakening of the immune system caused by HIV.

Causes of HIV/AIDS

HIV is transmitted through contact with certain body fluids from a person who has the virus. Here are the primary ways HIV can be spread:

  • Unprotected sexual contact: Vaginal, anal, or oral sex with someone who has HIV without using a condom.
  • Sharing needles: Particularly among people who inject drugs.
  • From mother to child: During pregnancy, childbirth, or breastfeeding.
  • Blood transfusions or organ transplants: Though rare today due to rigorous screening processes.
  • Occupational exposure: Accidental needle sticks or contact with infected fluids in healthcare settings.

HIV is not spread by casual contact like hugging, shaking hands, sharing food, or through insect bites.

Symptoms of HIV/AIDS

The symptoms of HIV vary by stage:

Acute HIV Infection (2–6 weeks after exposure):

  • Flu-like symptoms: fever, sore throat, muscle aches.
  • Swollen lymph nodes.
  • Rash.
  • Headache.
  • Fatigue.
    These symptoms can last for a few weeks and may be mistaken for a common viral infection.

Clinical Latency Stage (Chronic HIV):

  • Often no symptoms.
  • Virus is still active and slowly damaging the immune system.
  • This stage can last several years, especially with treatment.

AIDS (Advanced Stage):

  • Rapid weight loss.
  • Recurring fever or night sweats.
  • Extreme fatigue.
  • Prolonged swelling of lymph nodes.
  • Chronic diarrhea.
  • Sores in the mouth, anus, or genitals.
  • Pneumonia.
  • Neurological disorders (memory loss, confusion).
  • Certain cancers like Kaposi’s sarcoma or lymphoma.

Types of HIV/AIDS

HIV is generally classified into two main types:

1. HIV-1:

  • The most common type worldwide.
  • More aggressive and more likely to progress to AIDS if untreated.

2. HIV-2:

  • Less common, mostly found in West Africa.
  • Progresses more slowly and is less transmissible.

In terms of disease progression, HIV infection itself is divided into stages:

  • Acute infection: High viral load; highly infectious.
  • Chronic infection: Virus reproduces at low levels.
  • AIDS: Severe immune system damage with life-threatening infections or cancers.

While the virus itself is categorized into HIV-1 and HIV-2, doctors and researchers also describe different clinical stages based on CD4 count and opportunistic infections.

Tests Used to Detect HIV/AIDS

Detecting HIV early is crucial for starting treatment and preventing progression to AIDS. Key tests include:

1. Antibody Tests:

  • Detect antibodies the body makes against HIV.
  • Examples: Rapid tests and ELISA (enzyme-linked immunosorbent assay).
  • May take several weeks after infection to become positive (window period).

2. Antigen/Antibody Combination Tests (Fourth-generation tests):

  • Detect both HIV antibodies and p24 antigen (a part of the virus).
  • Can identify infection earlier than antibody-only tests.

3. Nucleic Acid Tests (NAT):

  • Detect HIV’s genetic material (RNA).
  • Highly sensitive; used when very recent infection is suspected.

4. CD4 Count:

  • Measures the number of CD4 cells in the blood.
  • Helps assess immune system health.

5. HIV Viral Load Test:

  • Measures the amount of HIV in the blood.
  • Used to monitor treatment effectiveness.

Conclusion

HIV/AIDS is no longer the death sentence it was once feared to be. With medical advances, people living with HIV can now expect a near-normal life expectancy—if diagnosed early and treated properly. Despite this progress, stigma, fear, and lack of awareness remain significant barriers to testing and care. Understanding how HIV is transmitted, recognizing early symptoms, and knowing the available tests can save lives. Remember, the virus itself doesn’t discriminate—but awareness, testing, and treatment can make all the difference.

Frequently Asked Questions (FAQs)

1. What is HIV?
HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system, weakening the body’s defense against infections.

2. What does AIDS mean?
AIDS (Acquired Immunodeficiency Syndrome) is the most advanced stage of HIV infection, marked by severe immune system damage and life-threatening infections or cancers.

3. How can HIV be transmitted?
Through unprotected sex, sharing needles, from mother to child during birth or breastfeeding, and rarely via contaminated blood transfusions.

4. Is there a cure for HIV?
Currently, there’s no cure, but antiretroviral therapy (ART) can control the virus, allowing people to live long, healthy lives.

5. What are the early symptoms of HIV?
Flu-like symptoms such as fever, sore throat, rash, swollen lymph nodes, and fatigue.

6. Can someone with HIV look healthy?
Yes, many people live symptom-free for years, especially with treatment.

7. How is HIV diagnosed?
Through tests like antibody tests, antigen/antibody combination tests, and nucleic acid tests (NAT).

8. Can HIV progress to AIDS without treatment?
Yes, untreated HIV typically progresses to AIDS, leading to severe complications and opportunistic infections.

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