Dr. Nikunj Jain
Co-Founder and HOD - Nuclear Medicine ,MBBS, DRM, DNB, FEBNM, FANMB, Dip. CBNC
Vaccination is one of the greatest achievements of modern medicine. It has saved millions of lives by preventing deadly diseases, from smallpox to COVID-19. But how do vaccines actually work? Why are booster shots necessary? And what’s the difference between the types of vaccines available today?
Let’s decode the science behind vaccination, understand its types, and explore how it keeps both individuals and communities safe.
Vaccination is the process of administering a vaccine to help your body develop immunity against specific infections. Vaccines contain harmless versions (or parts) of a disease-causing microorganism — like a virus or bacterium. These “train” your immune system to recognize and fight the real infection if it ever enters your body.
In simple terms, vaccination prepares your immune system in advance, so it can protect you without you ever falling sick.
When you get vaccinated, your immune system recognizes the antigens (foreign substances) from the vaccine. In response, it produces antibodies — special proteins that can destroy or neutralize those antigens.
If your body encounters the real pathogen later, these antibodies quickly identify and destroy it. This response is called immunity.
Some vaccines provide lifelong protection (like the measles vaccine), while others require booster doses to maintain immunity (like the tetanus vaccine).
Not all vaccines are created the same way. Modern medicine offers different types depending on the infection and immune response required.
These contain a weakened form of the pathogen.
Examples: Measles, Mumps, Rubella (MMR), Chickenpox, and Yellow Fever vaccines.
Note: Not recommended for people with weak immune systems.
These contain dead microorganisms or parts of them.
Examples: Polio (IPV), Hepatitis A, Rabies.
Benefit: Safe for people with compromised immunity.
Instead of the microorganism, these use inactivated toxins produced by bacteria.
Examples: Tetanus and Diphtheria vaccines.
These use specific parts (proteins or sugars) of the pathogen to trigger immunity.
Examples: HPV, Hepatitis B, and Pneumococcal vaccines.
A modern innovation that teaches cells to produce a harmless piece of the virus (like the COVID-19 spike protein) to trigger immunity.
Examples: Pfizer-BioNTech and Moderna COVID-19 vaccines.
These use a harmless virus (like an adenovirus) to deliver genetic material from the target pathogen.
Examples: Oxford-AstraZeneca COVID-19 vaccine.
A proper immunization schedule ensures protection at every life stage.
In India, the National Immunization Schedule (NIS) recommends vaccines such as:
Consult your healthcare provider for your personalized vaccination plan — especially if you have chronic illnesses or travel frequently.
| Myth | Fact |
|---|---|
| Vaccines cause the diseases they prevent | Vaccines use inactive or weakened forms; they cannot cause the disease |
| Natural immunity is better | It comes with serious risks like infection or death |
| Vaccines cause autism | Numerous scientific studies have proven this false |
| Adults don’t need vaccines | Boosters and seasonal shots are crucial for adults too |
| Too many vaccines overload the immune system | The immune system can handle thousands of antigens daily |
Most vaccines cause mild and short-lived side effects such as:
Severe allergic reactions are extremely rare. Always inform your doctor about allergies or medical history before vaccination.
When 80–90% of a population is immunized, it creates herd immunity — protecting even those who are unvaccinated. This principle is why vaccination campaigns are critical for eradicating diseases and preventing epidemics.
The COVID-19 pandemic highlighted how vital vaccination is for global health. Modern vaccines are now being developed for:
With ongoing research, personalized and genetic-based vaccines are expected to revolutionize preventive healthcare in the next decade.
Vaccination introduces harmless antigens into your body, helping your immune system learn to recognize and fight infections before they make you sick.
Vaccines protect you from serious diseases, prevent outbreaks, and save millions of lives globally every year.
They include live attenuated, inactivated, subunit, toxoid, mRNA, and vector-based vaccines.
Yes, vaccines go through rigorous testing and monitoring. However, people with specific health conditions should consult a doctor first.
Adults need periodic boosters (like tetanus), annual flu shots, and specific vaccines based on age and health conditions.
Minor side effects like mild fever or soreness are normal. Serious reactions are very rare.
It’s when enough people are vaccinated to stop disease spread, protecting even the unvaccinated population.
Children’s immune systems are still developing, and early vaccination helps protect them from potentially deadly infections.
Yes. All approved COVID-19 vaccines have been proven safe and effective in preventing severe illness and death.
Vaccines are available at government hospitals, health centers, and authorized private clinics nationwide.
Vaccination is not just a medical procedure — it’s a commitment to health and community safety. Whether it’s for your child, yourself, or your elderly parents, staying updated with vaccines is one of the most effective ways to protect your future.
If you’re unsure about your vaccination status, talk to your healthcare provider or book a preventive health checkup at Molecular Diagnostics to stay protected and informed.
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